PT  - JOURNAL ARTICLE
AU  - Jirsová, Zuzana
AU  - Kučera, Tomáš
AU  - Martínek, Jindřich
AU  - Liška, František
AU  - Křenová, Drahomíra
AU  - Křen, Vladimír
TI  - ALTERED SPERMATOGENESIS IN THE HYPODACTYLOUS RATS
DP  - 2004 Dec 1
TA  - Biomedical papers
PG  - 213--215
VI  - 148
IP  - 2
AID - 10.5507/bp.2004.042
IS  - 12138118
AB  - Germinal epithelium of seminiferous tubules in adult, infertile hypodactylous males displays significant reduction in the number of germ-line cells. Detection of apoptosis in the germ-line cells during postnatal differentiation was performed to elucidate the mechanism of the decreased number of germ cells in the testes of adult rats. Evaluation of DNA fragmentation and expression of activated caspase-3 in germ cells did not confirm marked germ cell death during the onset of spermatogenesis as a main cause of significant reduction of germ cells in Hd/Hd testes of adult males. The primary cause of spermatogenesis deffect seems to be rather associated with a disorder in the cell cycle regulation and interrelation of germ-line cells with Sertoli cells.