RT Journal Article
SR Electronic
A1 Lazárová, Marie
A1 Stejskal, David
A1 Lačňák, Bořek
A1 Václavík, Jan
A1 Adamovská, Sylva
A1 Ochmanová, Radka
A1 Hanák, Václav
A1 Skácelová, Martina
T1 THE ANTIOXIDANT ACETYLCYSTEINE REDUCES OXIDATIVE STRESS BY DECREASING LEVEL OF AOPPS
JF Biomedical papers
YR 2004
VO 148
IS 2
SP 131
OP 133
DO 10.5507/bp.2004.023
UL https://biomed.papers.upol.cz/artkey/bio-200402-0004.php
AB Oxidative stress and especially its connection with many diseases has been discussed much recently. Among markers of oxidative stress there appear new and quite specific ones called advanced oxidation protein products (AOPPs). We tried to influence the level of AOPPs by an antioxidant therapy with N-acetylcysteine. Fourteen individuals with many cardiovascular risk factors were examined. All these patients were administered acetylcysteine (NAC) 600 mg/day orally during 20 days. Before starting the therapy we determined AOPP, albumin cobalt binding (ACB), glucose, creatinine, urea, ALT, AST, cholesterol, LDL, HDL and triglycerides values in peripheral venous blood in all individuals. After finishing our intervention we determined AOPP, ACB and glucose level again. Our results show a statistically significant decrease in AOPP levels after 20-day N-acetylcysteine therapy (medians, initially 82.2, at study end 74.3 umol/l, p = 0.039). We demonstrate a significant decrease in AOPP levels after 20-day N-acetylcysteine therapy in dose 600 mg/day.