PT Journal AU Mares, J Stejskal, D Vavrouskova, J Urbanek, K Herzig, R Hlustik, P TI USE OF CYSTATIN C DETERMINATION IN CLINICAL DIAGNOSTICS SO Biomedical papers PY 2003 BP 177 EP 180 VL 147 IS 2 DI 10.5507/bp.2003.025 DE Keywords: Cystatin C / Biochemical diagnostics / Alzheimer's dementia / Early atherosclerosis / Vascular aneurysms / Hyperhomocysteinaemia / Neurodegenerative diseases AB This paper presents a current view of the possible clinical uses of cystatin C determination. Cystatin C is an inhibitor of cysteine proteases, and relatively stable in the systemic circulation it is comparatively easily determined. Although in clinical practice it is known primarily as a relatively reliable and endogenous marker for glomerular filtration, lately cystatin C analysis has been discussed in connection with the diagnostics of a variety of diseases such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases. ER