RT Journal Article
SR Electronic
A1 Gallo, Jiří
A1 Kolář, Milan
A1 Novotný, Radek
A1 Řiháková, Petra
A1 Tichá, Vlasta
T1 PATHOGENESIS OF PROSTHESIS-RELATED INFECTION
JF Biomedical papers
YR 2003
VO 147
IS 1
SP 27
OP 35
DO 10.5507/bp.2003.004
UL https://biomed.papers.upol.cz/artkey/bio-200301-0004.php
AB In spite of its incidence decreasing to 1% nowadays, prosthesis-related infection remains a research, diagnostic, therapeutic and cost-related problem. It can be defined as a presence of bacteria in the artificial joint space, which is significantly associated with evident laboratory and/or tissue markers, and clinical signs of running infection. We believe that the more precise understanding of pathogenesis, the more effective preventative and therapeutic measures, and the lower infection rate. The implants are colonized by airborne, skin-, and/ or surgeon-related bacteria during surgery despite being operated in closely respected operating regime. Some prosthetic characteristics are advantageous and may play important roles in the process of bacterial adherence. After successful attachment on the biomaterial surface bacteria multiply and physiologically transform into a "biofilm" community, making them much more resistant to antibiotic therapy and host immunity. Bacterial resistance is a complex phenomenon influenced by intrinsic and extrinsic factors, including the cell configuration in the biofilm community. So the cure of periprosthetic sepsis without removing of all foreign bodies and necrotic bone fragments is often ineffective. Acute hematogenous sepsis is suggestive of a distortion of a previously aseptic joint space by invasion of bacteria through the vessels.