RT Journal Article
SR Electronic
A1 Ehrmann, Jiří
A1 Vavrušová, Nicol
A1 Collan, Yrjo
A1 Kolář, Zdeněk
T1 Peroxisome proliferator-activated receptors (PPARs) in health and disease.
JF Biomedical papers
YR 2002
VO 146
IS 2
SP 11
OP 14
DO 10.5507/bp.2002.002
UL https://biomed.papers.upol.cz/artkey/bio-200202-0002.php
AB Peroxisome proliferator-activated receptors (PPARs) belong to the superfamily of steroid-thyroid-retinoid nuclear receptors. PPARs are transcription factors activated by specific ligands and play an important role during cell signalling. Intensive study of PPARs during recent years has revealed their importance in both normal physiology and in the pathology of various tissues. They participate in the regulation of lipid metabolism, inflammation and the development of atherosclerosis or diabetes. They also play a role in the regulation of growth and differentiation of cancer. It has been suggested that PPAR ligands may have potent anticancer effects and thereFirst may serve as potential anticancer drugs. In this review we focus on a role of PPARs in breast cancer and in glial tumors of the brain.