RT Journal Article
SR Electronic
A1 Kopeček, Petr
A1 Altmannová, Karla
A1 Weigl, Evžen
T1 STRESS PROTEINS: NOMENCLATURE, DIVISION AND FUNCTIONS
JF Biomedical papers
YR 2001
VO 145
IS 2
SP 39
OP 47
DO 10.5507/bp.2001.010
UL https://biomed.papers.upol.cz/artkey/bio-200102-0005.php
AB The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced byexposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecularchaperones in regulating cellular homeostasis and promoting survival. If the stress is too severe, a signal that leadsto programmed cell death, apoptosis, is activated, thereby providing a finely tuned balance between survival anddeath. In addition to extracellular stimuli, several nonstressful conditions induce Hsps during normal cellulargrowth and development. The enhanced heat shock gene expression in response to various stimuli is regulated byheat shock transcription factors.