RT Journal Article
SR Electronic
A1 Laurincová, Beáta
T1 INTERLEUKIN-1 FAMILY: FROM GENES TO HUMAN DISEASE
JF Biomedical papers
YR 2000
VO 144
IS 1
SP 19
OP 30
DO 10.5507/bp.2000.002
UL https://biomed.papers.upol.cz/artkey/bio-200001-0002.php
AB Interleukin-1 (IL-1) is one of the most potent proinflammatory cytokines involved both in physiologicalimmune responses and in the development of various immunopathological disorders. The members of IL-1 familyform a complex system with tight regulatory mechanisms and clarifying their role in disease remains in the centre ofresearch interests. This review article except of summarising recent findings about IL-1 family members focuses onassociations of IL-1 gene complex polymorphisms with human diseases.