PT  - JOURNAL ARTICLE
AU  - Laurincová, Beáta
TI  - INTERLEUKIN-1 FAMILY: FROM GENES TO HUMAN DISEASE
DP  - 2000 Jul 1
TA  - Biomedical papers
PG  - 19--30
VI  - 144
IP  - 1
AID - 10.5507/bp.2000.002
IS  - 12138118
AB  - Interleukin-1 (IL-1) is one of the most potent proinflammatory cytokines involved both in physiologicalimmune responses and in the development of various immunopathological disorders. The members of IL-1 familyform a complex system with tight regulatory mechanisms and clarifying their role in disease remains in the centre ofresearch interests. This review article except of summarising recent findings about IL-1 family members focuses onassociations of IL-1 gene complex polymorphisms with human diseases.