PT Journal
AU Laurincova, B
TI INTERLEUKIN-1 FAMILY: FROM GENES TO HUMAN DISEASE
SO Biomedical papers
PY 2000
BP 19
EP 30
VL 144
IS 1
DI 10.5507/bp.2000.002
DE Interleukin-1 / Interleukin-1 receptor antagonist / Gene polymorphism
AB Interleukin-1 (IL-1) is one of the most potent proinflammatory cytokines involved both in physiologicalimmune responses and in the development of various immunopathological disorders. The members of IL-1 familyform a complex system with tight regulatory mechanisms and clarifying their role in disease remains in the centre ofresearch interests. This review article except of summarising recent findings about IL-1 family members focuses onassociations of IL-1 gene complex polymorphisms with human diseases.
ER