PT Journal
AU Gibejova, A
TI CHEMOKINE RECEPTORS
SO Biomedical papers
PY 2000
BP 9
EP 18
VL 144
IS 1
DI 10.5507/bp.2000.001
DE Chemokines / Chemokine receptors / Polymorphisms / Knockout mice / Function in vivo
AB Chemokines mediate their multiple effects by binding to a variety of specific receptors, that comprise a subfamilyof rhodopsin-like, 7-transmembrane domain receptors, coupled to G proteins. Some of these receptors serve ascoreceptors for HIV, some of them could be expressed as markers for T lymphocyte functional differentiation. Thisreview aims at summarising data on chemokine receptors, their function in vivo, their target cells and it alsomentions association of chemokine receptor polymorphisms with human disease.
ER