RT Journal Article
SR Electronic
A1 Příborský, Jan
A1 Kikuchi, Katsuya
A1 Takayama, Kozo
A1 Nagai, Tsuneji
T1 PERCUTANEOUS ABSORPTION OF DISOPYRAMIDE, LIDOCAINE AND TRIMECAINE
JF Biomedical papers
YR 1998
VO 141
IS 1
UL https://biomed.papers.upol.cz/artkey/bio-199801-0006.php
AB Promoting effect of cyclic monoterpenes on percutaneous absorption of antiarrhytmic drugs disopyramide, lidocaine andtrimecaine was investigated in the rats. Laurocapram (Azone) was used as a standard comparator of penetration enhancement.The absorption of trimecaine was significantly enhanced by addition of limonene, trans-p-menthane and Azone in1% concentration. Lidocaine and disopyramide penetrated across the skin only when 1% of limonene was used. Othercyclic monoterpenes showed no effect on percutaneous absorption of examined drugs.