PT  - JOURNAL ARTICLE
AU  - Příborský, Jan
AU  - Kikuchi, Katsuya
AU  - Takayama, Kozo
AU  - Nagai, Tsuneji
TI  - PERCUTANEOUS ABSORPTION OF DISOPYRAMIDE, LIDOCAINE AND TRIMECAINE
DP  - 1998 Jul 1
TA  - Biomedical papers
VI  - 141
IP  - 1
IS  - 12138118
AB  - Promoting effect of cyclic monoterpenes on percutaneous absorption of antiarrhytmic drugs disopyramide, lidocaine andtrimecaine was investigated in the rats. Laurocapram (Azone) was used as a standard comparator of penetration enhancement.The absorption of trimecaine was significantly enhanced by addition of limonene, trans-p-menthane and Azone in1% concentration. Lidocaine and disopyramide penetrated across the skin only when 1% of limonene was used. Othercyclic monoterpenes showed no effect on percutaneous absorption of examined drugs.