PT Journal
AU Priborsky, J
   Kikuchi, K
   Takayama, K
   Nagai, T
TI PERCUTANEOUS ABSORPTION OF DISOPYRAMIDE, LIDOCAINE AND TRIMECAINE
SO Biomedical papers
PY 1998
VL 141
IS 1
DE Antiarrhytmic drugs / Penetration enhancer / Cyclic monoterpenes
AB Promoting effect of cyclic monoterpenes on percutaneous absorption of antiarrhytmic drugs disopyramide, lidocaine andtrimecaine was investigated in the rats. Laurocapram (Azone) was used as a standard comparator of penetration enhancement.The absorption of trimecaine was significantly enhanced by addition of limonene, trans-p-menthane and Azone in1% concentration. Lidocaine and disopyramide penetrated across the skin only when 1% of limonene was used. Othercyclic monoterpenes showed no effect on percutaneous absorption of examined drugs.
ER