Biomedical papers - Ahead of Print

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. X:X | 10.5507/bp.2018.019

Treatment of retinal capillary hemangioma using 810 nm infrared laser

Pavel Pochop, Martina Kodetova, Dagmar Dotrelova
Department of Ophthalmology for Children and Adults, Second Faculty of Medicine, Charles University, Prague and University Hospital Motol, Prague, Czech Republic

Aim: Presentation of the efficacy of infrared laser for the treatment of retinal capillary hemangioma (RCH).

Methods: The treatment and follow-up of nine eyes (fourteen tumors of different sizes and localizations) in seven patients (five children) with RCH. Infrared diode laser (810 nm) was used for modified transpupillary thermotherapy (TTT) in long exposition mode and power between 200 and 1200 mW with a beam diameter of 2 mm (indirect ophthalmoscope, +28 D or +40 D lens) or 0.5 mm-3 mm (slit-lamp) depending on the diameter and localisation of the hemangioma.

Results: We achieved complete destruction of the tumor with flat chorioretinal atrophic scar in all cases. Only one tumor regrowth was observed and re-treatment in this case was necessary. Treatment was combined with brachytherapy in a one case. There was one serious complication- total exudative retinal detachment, causing permanent deterioration in visual acuity despite pars plana vitrectomy (PPV). Other complications such as haze and vitreal hemorrhage were transient. The final best corrected visual acuity (BCVA) ranged from 20/20 to counting fingers at 2 feet.

Conclusion: Infrared laser can be considered an acceptable therapeutic option for RCH especially for centrally localized lesions. We believe that the role of this therapy will increase in the future.

Keywords: retinal capillary hemangioma, infrared diode laser, transpupillary thermotherapy, treatment, von Hipple-Lindau

Received: January 14, 2018; Accepted: April 13, 2018; Prepublished online: May 16, 2018


  1. Singh AD, Shields JA, Shields CL. Solitary retinal capillary hemangioma. Hereditary (von Hippel-Lindau disease) or nonhereditary? Archives of Ophthalmology 2001;119:232-4.
  2. Lanzetta P, Virgili G, Ferrari E, Menchini U. Diode laser photocoagulation of choroidal hemangioma. Int Ophthalmol 1995;19:239-47.
  3. Parmar DN, Mireskandari K, McHugh D. Transpupillary Thermotherapy for retinal Capillary Hemangioma in von Hippel-Lindau Disease. Ophthalmic Surg Lasers 2000;31:334-6.
  4. Saitta A, Nicolai M, Giovannini A, Mariotti C. Juxtapapillary Retinal Capillary Hemangioma: New Therapeutic Strategies. Med Hypothesis Discov Innov Ophthalmol 2014;3:71-5.
  5. Singh AD, Nouri M, Shields CL, Shields JA, Perez N. Treatment of retinal capillary hemangioma. Ophthalmology 2002;109:1799-806.
  6. Milewski SA. Spontaneous regression of a capillary hemangioma of the optic disc. Arch Ophthalmol 2002;120:1100-1.
  7. Shields JS. Response of Retinal Capillary Hemangioma to Cryotherapy. Arch Ophthalmol 1993;111:551.
  8. Kreusel KM, Bornfeld N, Lommatzsch A, Wessing A, Foerster MH. Ruthenium-106 brachytherapy for peripheral retinal capillary hemangioma. Ophthalmology 1998;105:1386-92.
  9. Singh AD, Shields CL, Shields JA. von Hippel-Lindau disease. Surv Ophthalmol 2001;46:117-42.
  10. Garcia-Arumi J, Sararols LH, Cavero L, Escalada F, Corsostegui BF. Therapeutic Options for Capillary Papillary Hemangiomas. Ophthalmology 2000;107:48-54.
  11. Pilbauer J, Hejdukova I, Pasta J, Pochop P, Vladyka V, Liscak D, Simonova G. Personal experience with treatment of vascular diseases using the Leksell gamma knife (in Czech). Cesk Slov Oftalmol 1998;54:235-40.
  12. Seibel I, Cordini D, Hager A, Riechardt AI, Klein JP, Heufelder J, Moser L, Joussen AM. Long-term results after proton beam therapy for retinal papillary capillary hemangioma. Am J Ophthalmol 2014;158:381-6.
  13. Archer DB, Amoaku WMK, Kelly G. Choroidoretinal neovascularisation following radon seed treatment of retinoblastoma in two patients. Br J Ophthalmol 1993;77:95-9.
  14. Mariotti C, Giovannini A, Reibaldi M, Nicolai M, Saitta A. 25-gauge vitrectomy combined with half-fluence photodynamic therapy for the treatment of juxtapapillary retinal capillary hemangioma: a case report. Case Rep Ophthalmol 2014;5:162-7.
  15. Matuskova V, Vyslouzilová D. The Use of anti-VEGF preparations and PDT in the treatment of retinal juxtapapillary hemangioma - a case report. Cesk Slov Oftalmol 2014;70:196-200.
  16. Agarwal A, Kumari N, Singh R. Intravitreal bevacizumab and feeder vessel laser treatment for a posteriorly located retinal capillary hemangioma. Int Ophthalmol 2016;36:747-50. doi: 10.1007/s10792-016-0183-x Go to original source...
  17. Hyeong MK, Kyu HP, Se JW. Massive Exudative Retinal Detachment Following Photodynamic Therapy and Intravitreal Bevacizumab Injection in Retinal Capillary Hemangioma. Korean J Ophthalmol 2015;29:143-5.