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Jan Václavík, MD, Ph.D. (born 1979) is an associate professor at the Faculty of Medicine and Dentistry of Palacky University (Czech Republic). He received his Ph.D. in Internal Medicine from Palacky University in 2010. His research interests include hypertension, preventive cardiology, heart failure and cardiovascular therapeutics. He is the Head of Hypertension Excellence Center of the University Hospital in Olomouc, the member of the European Society of Hypertension and the European Society of Cardiology. He is married and has 2 children.
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Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. X:X
Giant adrenocortical carcinoma with 27-month disease-free survival by surgical resection alone: A case report
- Martin Strakaa, Renata Soumarovab, Jan Bulejcikc, Martin Banikd, Mikulas Purae, Matej Skrovinaa
- a Department of Surgery, Comprehensive Cancer Centre, Hospital Novy Jicin, Novy Jicin, Czech Republic
- b Department of Oncology and Radiotherapy, Comprehensive Cancer Centre, Hospital Novy Jicin, Novy Jicin
- c Department of Vascular and Minimally Invasive Surgery, Hospital Podlesi, Trinec
- d Department of Pathology, Comprehensive Cancer Centre, Hospital Novy Jicin, Novy Jicin
- e Department of Endocrinology, National Institute of Endocrinology and Diabetology, Lubochna, Slovakia
Keywords: adrenocortical carcinoma, adrenal tumour, surgical resection, disease-free survival
Received: January 21, 2013; Accepted: May 21, 2013; Available online: June 18, 2013
Background: Adrenocortical cancer (ACC) is a rare disease with an estimated incidence of 1-2/million/year. The tumour stage and completeness of surgical resection have the biggest impact on survival. Whereas stage I-II patients survive in 55-64% of cases, only 0-5% of patients with stage IV disease are still alive at 5 years. A median survival of 33 months can be expected after curative surgery. Incomplete surgery leads to a significant drop in survival.
Method: We present a 40-year-old man who underwent a technically demanding complete surgical excision of a giant (26 cm, 2372 g) ACC and experienced a 27-month disease-free survival without any systemic treatment. Detailed description of the surgical anatomy in relation to tumour size and patient body constitution is provided. The surgical strategy and exposure pitfalls under such extreme circumstances are discussed.
Conclusion: To achieve R0 resection in locally advanced disease, en bloc resection with neighbouring organs is widely recommended. Giant tumours may however pose a technical challenge due to space constraints.
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