PT Journal
AU Liang, S
   Hu, Z
TI Unveiling the predictive power of biomarkers in traumatic brain injury: A narrative review focused on clinical outcomes
SO Biomedical papers
PY 2025
BP 161
EP 178
VL 169
IS 3
DI 10.5507/bp.2024.038
DE traumatic brain injury; biomarkers; extracellular vesicles; non-coding RNAs; clinical outcomes
AB Traumatic brain injury (TBI) has long-term consequences, including neurodegenerative disease risk. Current diagnostic tools are limited in detecting subtle brain damage. This review explores emerging biomarkers for TBI, including those related to neuronal injury, inflammation, EVs, and ncRNAs, evaluating their potential to predict clinical outcomes like mortality, recovery, and cognitive impairment. It addresses challenges and opportunities for implementing biomarkers in clinical practice, aiming to improve TBI diagnosis, prognosis, and treatment.
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