RT Journal Article
SR Electronic
A1 Spisarova, Martina
A1 Losse, Stanislav
A1 Jakubec, Petr
A1 Hartmann, Igor
A1 Kral, Milan
A1 Ehrmann, Jiri
A1 Szkorupa, Marek
A1 Studentova, Hana
A1 Melichar, Bohuslav
T1 Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literature
JF Biomedical papers
YR 2024
VO 168
IS 2
SP 181
OP 186
DO 10.5507/bp.2022.051
UL https://biomed.papers.upol.cz/artkey/bio-202402-0012.php
AB Objective. Intravesical administration of bacillus Calmette-Guérin is standard adjuvant treatment of non-muscle invasive bladder cancer. In spite of the fact that this immunotherapy is locoregional, there are still risk of some complications. Methods. We describe two cases of systemic BCG infection after intravesical administration of BCG vaccine in patients with early stage of bladder cancer. Results. Both patients suffered from systemic BCG infection manifesting as BCG pneumonitis. After standard therapy with antituberculotic agents, both of them fully recovered. Conclusion. BCG infection can occur as a rare but potentially serious complication of this treatment procedure. Gravity of this side effect and its specific therapy require prompt and right diagnosis.