RT Journal Article
SR Electronic
A1 Ecsiova, Dominika
A1 Kamaradova, Katerina
A1 Nova, Marketa
A1 Hoffmann, Petr
A1 Rozsivalova, Petra
A1 Simkovic, Martin
A1 Zak, Pavel
T1 Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report
JF Biomedical papers
YR 2023
VO 167
IS 4
SP 385
OP 389
DO 10.5507/bp.2022.026
UL https://biomed.papers.upol.cz/artkey/bio-202304-0013.php
AB Background. Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disease with an accumulation of mature B lymphocytes with fine reticular chromatin and cytoplasm with typical hairy-like cytoplasmic projections. Rarely, hairy cell leukemia manifests as a lung infiltration. The differential diagnosis between infection and malignant involvement with hairy cell leukemia is often challenging in such situations.
Methods and Results. We present a 53-year-old female with an uncommon pulmonary involvement with hairy cell leukemia. In addition, we discuss the complicated differential diagnosis of pulmonary disease in patients with hairy cell leukemia and the treatment approach to these patients.
Conclusion. This case report describes the successful therapy management of a patient with pulmonary involvement by hairy cell leukemia. Therapy with interferon-alfa and cladribine resulted in long-term remission of the underlying disease.