RT Journal Article
SR Electronic
A1 Pink, Richard
A1 Michalek, Jaroslav
A1 Kral, David
A1 Mozola, Michal
A1 Benes, Pavel
A1 Lenka, Saskova
A1 Dvorak, Zdenek
T1 Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx
JF Biomedical papers
YR 2023
VO 167
IS 2
SP 139
OP 144
DO 10.5507/bp.2021.062
UL https://biomed.papers.upol.cz/artkey/bio-202302-0006.php
AB Aims. The objective of this study was to compare bone invasion type with histopathological, clinical and immunohistochemical prognostic factors. Methods. The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 patients, with presence of bone invasion on histopathology, were divided according to the type of bone invasion (erosive, infiltrative, mixed). Each invasion type was compared to microvascular density using the CD34 marker. Results. The bone invasion was observed in 30 out of 49 patients (61.22%). On McNemar's test, statistically significant association was observed between bone invasion types and histopathological grade. In contrast, no significant correlation was observed between bone invasion type, and tumour volume or nodal metastases. In tumours with bone invasion of the infiltrative type, higher frequency of locoregional relapses was observed. The 5-year survival, since diagnosis, was approximately 60% in the erosive group, 40% in the mixed group, and merely 15% in the infiltrative group. Conclusion. Peritumoural microvascular density was not significantly related to bone invasion types. Whereas, a significantly higher intratumoural microvascular density was observed in infiltrative type of the bone invasion, when compared to the erosive and mixed type.