PT Journal AU Obrova, J Sovova, E Kocianova, E Taborsky, M TI Sudden cardiac death - a known unknown? SO Biomedical papers PY 2022 BP 258 EP 266 VL 166 IS 3 DI 10.5507/bp.2021.065 DE sudden cardiac death; mechanism; prevention; risk stratification; implantable cardioverter-defibrillator AB Sudden cardiac death (SCD) is a major medical, economic and social problem. The estimated annual number of SCDs is approximately 4 million cases worldwide. Approximately 50% of SCDs are unexpected first manifestations of cardiac disease. The survival rate after out-of-hospital cardiac arrest is low even in countries with the most advanced health care systems. It all emphasizes the importance of prevention, in which implantable cardioverter-defibrillators play a dominant role. However, our ability to recognize high-risk patients remains insufficient. Moreover, a declining rate of shockable rhythm as the initial recording has been reported in the last decades. Despite numerous SCD studies and undisputed progress, there are still many unanswered questions. ER