RT Journal Article
SR Electronic
A1 Muri, Jozef
A1 Chylikova, Jaroslava
A1 Skarda, Jozef
A1 Miklosova, Maria
A1 Kamarad, Vojtech
T1 The role of tumor-associated macrophages in solid malignancies - an overview of current knowledge
JF Biomedical papers
YR 2022
VO 166
IS 2
SP 136
OP 139
DO 10.5507/bp.2021.070
UL https://biomed.papers.upol.cz/artkey/bio-202202-0002.php
AB Tumor-associated macrophages are an important part of the tumor microenvironment. The presence of certain populations of macrophages within tumor tissue may be associated with either better or worse disease prognosis. The study of these cells is currently receiving a great deal of attention, with the most important topics of investigation raised being: the typification of subpopulations of tumor-associated macrophages; identification of the prognostic significance of population density and distribution of macrophages in the tumor microenvironment; ways to influence macrophage activity, migration and differentiation within the tumor. The answers to these questions can improve the efficiency of immunoterapy for malignancies. The presented article briefly reviews recent findings on tumor-associated macrophages in solid malignancies.