PT  - JOURNAL ARTICLE
AU  - Muri, Jozef
AU  - Chylikova, Jaroslava
AU  - Skarda, Jozef
AU  - Miklosova, Maria
AU  - Kamarad, Vojtech
TI  - The role of tumor-associated macrophages in solid malignancies - an overview of current knowledge
DP  - 2022 May 13
TA  - Biomedical papers
PG  - 136--139
VI  - 166
IP  - 2
AID - 10.5507/bp.2021.070
IS  - 12138118
AB  - Tumor-associated macrophages are an important part of the tumor microenvironment. The presence of certain populations of macrophages within tumor tissue may be associated with either better or worse disease prognosis. The study of these cells is currently receiving a great deal of attention, with the most important topics of investigation raised being: the typification of subpopulations of tumor-associated macrophages; identification of the prognostic significance of population density and distribution of macrophages in the tumor microenvironment; ways to influence macrophage activity, migration and differentiation within the tumor. The answers to these questions can improve the efficiency of immunoterapy for malignancies. The presented article briefly reviews recent findings on tumor-associated macrophages in solid malignancies.