RT Journal Article
SR Electronic
A1 Mrozek, Jan
A1 Necasova, Tereza
A1 Svoboda, Michal
A1 Simkova, Iveta
A1 Jansa, Pavel
T1 Prediction Score for persisting perfusion defects after pulmonary embolism
JF Biomedical papers
YR 2020
VO 164
IS 4
SP 394
OP 400
DO 10.5507/bp.2019.033
UL https://biomed.papers.upol.cz/artkey/bio-202004-0007.php
AB Aims: Long-term persistence of perfusion defect after pulmonaryembolism (PE) may lead to the development of chronic thromboembolic pulmonary hypertension. Identification of patients at risk of such a complication using a scoring system would be beneficial in clinical practice. Here, we aimed to derive a score for predicting persistence of perfusion defects after PE. Methods: 83 patients after PE were re-examined 6, 12 and 24 months after the PE episode. Data collected at the time of PE and perfusion status during follow-ups were used for modelling perfusion defects persistence using the Cox proportional hazards model and validated using bootstrap method. Results: A simple scoring system utilizing two variables (hemoglobin levels and age at the time of PE) was developed. Patients with hemoglobin levels over 140 g/L who were older than 65 years were at the highest risk of perfusion defects; in patients with the same hemoglobin levels and age <65 years, the risk was reduced by 79%, and by 89% in patients with hemoglobin <140 g/L. Conclusion: The proposed scoring system may be useful in clinical practice for identifying patients with high risk of persisting perfusion defects, flagging them for closer follow up, thus improving the effectiveness of long-term treatment of patients after PE.