RT Journal Article
SR Electronic
A1 Sidaraite, Agne
A1 Liutkeviciene, Rasa
A1 Glebauskiene, Brigita
A1 Vilkeviciute, Alvita
A1 Kriauciuniene, Loresa
T1 Associations of cholesteryl ester transfer protein (CETP) gene variants with pituitary adenoma
JF Biomedical papers
YR 2020
VO 164
IS 2
SP 189
OP 195
DO 10.5507/bp.2019.016
UL https://biomed.papers.upol.cz/artkey/bio-202002-0011.php
AB Aim: The aim was to evaluate the association of CETP (rs5882 and rs708272) single nucleotide polymorphisms with the presence, invasiveness, hormonal activity and recurrence of pituitary adenoma (PA). Methods: The study group included 142 patients with PA and the control group, 753 healthy subjects. The genotyping of CETP (rs5882 and rs708272) was performed using a real-time PCR method. Results: After statistical analysis we found that CETP rs708272 genotype G/A under the over-dominant model was associated with the decreased odds of PA (OR=0.637; 95%CI: 0.443-0.917; P=0.015), active PA (OR=0.538; 95%CI: 0.335-0.865; P =0.01) and non-recurrent PA (OR=0.602; 95% CI: 0.402 - 0.902; P =0.014). When compared to controls, the rs708272 genotype G/A was less frequent in the active PA subgroup (37.5% vs 52.7%, P =0.009) and the non-recurrent PA subgroup (40.2% vs 52.7%, P=0.013), while the rs5882 genotype A/A was less frequent in the non-recurrent PA subgroup (37.5% vs 46.2%, P=0.015). Conclusion: Our study showed that CETP rs708272 genotype G/A may be associated with a decreased risk of PA.