RT Journal Article
SR Electronic
A1 Olbertova, Helena
A1 Plevova, Karla
A1 Stranska, Kamila
A1 Pospisilova, Sarka
T1 Telomere dynamics in adult hematological malignancies
JF Biomedical papers
YR 2019
VO 163
IS 1
SP 1
OP 7
DO 10.5507/bp.2018.084
UL https://biomed.papers.upol.cz/artkey/bio-201901-0001.php
AB Telomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and end-to-end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often able to overcome this physiological barrier and become immortal with unlimited replicative capacity. In this review, we present current knowledge on the role of telomeres in human aging with a focus on their behavior in hematological malignancies of adults. Associations of telomere length to age-related diseases and to the prevention of telomere shortening are also discussed.