RT Journal Article
SR Electronic
A1 Stary, Lubomir
A1 Mezerova, Kristyna
A1 Skalicky, Pavel
A1 Zboril, Pavel
A1 Raclavsky, Vladislav
T1 Are we any closer to screening for colorectal cancer using microbial markers?A critical review
JF Biomedical papers
YR 2017
VO 161
IS 4
SP 333
OP 338
DO 10.5507/bp.2017.051
UL https://biomed.papers.upol.cz/artkey/bio-201704-0001.php
AB The role of gut microbiota in the development of sporadic colorectal cancer (CRC) is supported by a number of studies, however, the conclusiveness of published metagenomic studies is questioned by technical pitfalls and limited by small cohort sizes. In this review, we evaluate the current knowledge critically and outline practical solutions. We also list candidate CRC risk markers that are - in our opinion - well supported by available data and thus deserve clinical validation. Last but not least, we summarise available knowledge useful for improving care for patients immediately.