PT Journal
AU Stary, L
   Mezerova, K
   Skalicky, P
   Zboril, P
   Raclavsky, V
TI Are we any closer to screening for colorectal cancer using microbial markers?A critical review
SO Biomedical papers
PY 2017
BP 333
EP 338
VL 161
IS 4
DI 10.5507/bp.2017.051
DE colorectal cancer; microbiome; culturomics; screening markers
AB The role of gut microbiota in the development of sporadic colorectal cancer (CRC) is supported by a number of studies, however, the conclusiveness of published metagenomic studies is questioned by technical pitfalls and limited by small cohort sizes. In this review, we evaluate the current knowledge critically and outline practical solutions. We also list candidate CRC risk markers that are - in our opinion - well supported by available data and thus deserve clinical validation. Last but not least, we summarise available knowledge useful for improving care for patients immediately.
ER