RT Journal Article
SR Electronic
A1 Hornova, Jana
A1 Bortlicek, Zbynek
A1 Majkova, Petra
A1 Abrahamova, Jitka
A1 Kordikova, Drahomira
A1 Donatova, Zuzana
A1 Kupec, Martin
A1 Boublikova, Ludmila
A1 Dvorak, Josef
A1 Zapletal, Radek
A1 Buchler, Tomas
T1 Locally advanced breast cancer in elderly patients
JF Biomedical papers
YR 2017
VO 161
IS 2
SP 217
OP 222
DO 10.5507/bp.2017.011
UL https://biomed.papers.upol.cz/artkey/bio-201702-0014.php
AB Background: Although locally advanced breast cancer (LABC) is more common in the elderly population, there is little data on the clinical characteristics and survival of these patients. The aim of the present study was to compare different factors affecting survival in elderly patients with LABC. Methods: Retrospective analysis was carried out on a cohort of 80 patients aged 70 to 96 years, diagnosed with LABC defined as T3 N1, T4 N0, any N2 or N3, and M0. The prognostic impact of selected clinical parameters including age, comorbidities, tumour grade, HER2 status, tumour stage, local therapies, and systemic treatments was studied. Results: The median age of the patients was 79 years. The majority (n=53; 66%) had at least one significant comorbidity according to the Charlson score evaluation. The median overall survival was 50.6 months. As expected, hormonal therapy was the dominant mode of systemic treatment, but 24% also received at least one line of chemotherapy. Local therapies including surgery and/or radiotherapy were applied in 58% of patients. Conclusions: The diagnosis of LABC in the elderly is associated with poor prognosis. Age and serious comorbidities were negative prognostic factors.