RT Journal Article
SR Electronic
A1 Broz, Martin
A1 Steiner, Petr
A1 Salzman, Richard
A1 Hauer, Lukas
A1 Starek, Ivo
T1 The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance
JF Biomedical papers
YR 2016
VO 160
IS 3
SP 417
OP 422
DO 10.5507/bp.2016.027
UL https://biomed.papers.upol.cz/artkey/bio-201603-0013.php
AB Aims: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters
Methods: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis.
Results: Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative. The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P=0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients.
Conclusion: A tendency to differences in the survival of patients with ACC, depending on their MYB status. MYB negative patients were predisposed to better prognosis.