PT Journal
AU Broz, M
   Steiner, P
   Salzman, R
   Hauer, L
   Starek, I
TI The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance
SO Biomedical papers
PY 2016
BP 417
EP 422
VL 160
IS 3
DI 10.5507/bp.2016.027
DE adenoid cystic carcinoma; MYB gene; salivary gland; prognosis
AB Aims: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parametersMethods: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis.Results: Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative. The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P=0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients.Conclusion: A tendency to differences in the survival of patients with ACC, depending on their MYB status. MYB negative patients were predisposed to better prognosis.
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