RT Journal Article
SR Electronic
A1 Lovecek, Martin
A1 Skalicky, Pavel
A1 Klos, Dusan
A1 Bebarova, Linda
A1 Neoral, Cestmir
A1 Ehrmann, Jiri
A1 Zapletalova, Jana
A1 Svebisova, Hana
A1 Vrba, Radek
A1 Stasek, Martin
A1 Yogeswara, Tharani
A1 Havlik, Roman
T1 Long-term survival after resections for pancreatic ductal adenocarcinoma. Single centre study
JF Biomedical papers
YR 2016
VO 160
IS 2
SP 280
OP 286
DO 10.5507/bp.2016.011
UL https://biomed.papers.upol.cz/artkey/bio-201602-0016.php
AB Aim: To analyse the 5-year survival rate of patients undergoing radical surgery for pancreatic ductal adenocarcinoma (PDAC) and to identify prognostic factors.
Methods: A prospectively maintained database of 90 consecutive patients who underwent radical resection for PDAC was analysed. Survival was evaluated using the Kaplan-Meier method. Log-rank test and Cox regression analysis were used for the evaluation of prognostic factors. P values less than 0.05 were considered significant.
Results: Mean age (± standard deviation) was 63.2±8.6 years (female 28.9% and male 71.1%). Tumour localisation was in the head in 76 (84.5%), multifocal in 3 (3.3%) and in the body/tail in 11 (12.2%). Pancreatic head resection was performed in 75 (83.3%), total pancreatectomy in 4 (4.4%) and distal pancreatectomy with splenectomy in 11 (12.2%), with standard lymphadenectomy. Venous resection was in 4 (4.4%). Thirty-day and in-hospital mortality occurred in 1 (1.1%), 90-day mortality was 3.3%. On univariate analysis absence of perineural and vascular invasion, stage, absence of lymph node infiltration and no need for transfusion were associated with improved overall survival. On multivariate analysis vascular invasion HR=3.137 (95%CI: 1.692-5.816; P = 0.0003) and postoperative complications HR=2.004 (95%CI: 1.198-3.354; P = 0.008) were identified as significant independent predictors of survival. The five-year survival rate was 18.9%, with five-year recurrence-free survival of 16.7%.
Conclusion: Vascular invasion and postoperative complications were independent prognostic factors after curative resections of pancreatic cancer in studied cohort.