RT Journal Article
SR Electronic
A1 Hrabalek, Lumir
A1 Kalita, Ondrej
A1 Vaverka, Miroslav
A1 Zlevorova, Miloslava
A1 Ehrmann, Jiri
A1 Cechakova, Eva
A1 Adamus, Milan
A1 Novak, Vlastimil
A1 Langova, Katerina
T1 Resection versus biopsy of glioblastomas in eloquent brain areas
JF Biomedical papers
YR 2015
VO 159
IS 1
SP 150
OP 155
DO 10.5507/bp.2013.052
UL https://biomed.papers.upol.cz/artkey/bio-201501-0024.php
AB Aim: The aim of this study was to compare resection and biopsy of glioblastoma (GBM) in eloquent brain areas (EBA).
Methods:  This was a prospective evaluation of 38 patients with GBM in EBA. 22 were treated by surgical resection and 16 by biopsy. Preoperative KPS, neurological status and size of lesion on MRI were assessed. One week and three months postoperatively KPS, neurological status and Performance Status (PS) WHO were evaluated. Extent of resection (EOR) and overall survival (OS) were described. Overall mean age of the patients was 64.3 years, the mean lesion size in the resection group was 47.7 mm and in the biopsy group 51.0 mm.
Results:  Worsening or development of permanent neurological deficits 3 months after surgery were significantly lower in the resection group (23%), than the biopsy group (94%). In the resection group the median pre and postoperative KPS three months after surgery was 80.0. In the biopsy group the median pre and postoperative KPS was 68.1 one week after the procedure. In the resection group, 3 months after surgery, the median PS was 1, in the biopsy group one week after surgery the median PS was 2. The difference was statistically insignificant. The mean OS after resection was 12.2 months, and after biopsy 3.5 months. The difference was highly statistically significant. The mean EOR was 90%.
Conclusion:  This is the first prospective study, to our knowledge, that compares the results of resection and biopsy of primary GBM in EBA. For patients in good clinical condition with tumors in or near EBA, recommended is as radical resection of GBM as possible.