RT Journal Article
SR Electronic
A1 Larocca, Nancy
A1 Moreno, Dolores
A1 Garmendia, Jenny Valentina
A1 Velasquez, Olga
A1 Martin-Rojo, Joana
A1 Talamo, Carlos
A1 Garcia, Alexis
A1 De Sanctis, Juan Bautista
T1 Beta 2 adrenergic receptor polymorphisms, at codons 16 and 27, and bronchodilator responses in adult Venezuelan asthmatic patients
JF Biomedical papers
YR 2013
VO 157
IS 4
SP 374
OP 378
DO 10.5507/bp.2012.084
UL https://biomed.papers.upol.cz/artkey/bio-201304-0016.php
AB Background: One of the gene polymorphisms often studied in asthmatic patients is the β2 adrenergic receptor (ADRβ2). Even though in the Venezuelan Mestizo population there is a high incidence of asthma, there are no direct reports of ADRβ2 gene polymorphism, and treatment response. The aim of this study was to assess, in this population, the gene frequency of ADRβ2 polymorphisms at codons 16 Arg/Gly and 27 Gln/Glu, allergen sensitization, and its relationship to bronchodilator response.
Methods: Purified genomic DNA was obtained form 105 Mestizo asthmatic and 100 Mestizo healthy individuals from Venezuela. The two polymorphisms were assessed by PCR-RFLP. Patient sensitization to aeroallergens and their response to bronchodilatation were correlated.
Results: Significant differences between patients and controls were recorded in: 1) the prevalence of Arg/Arg at codon 16 (28.6% in patients vs. 47% in controls, P