RT Journal Article
SR Electronic
A1 Shukla, Deepika
A1 Dinesh Kale, Alka
A1 Hallikerimath, Seema
A1 Yerramalla, Venkatakanthaiah
A1 Subbiah, Vivekanandhan
A1 Mishra, Shashwat
T1 Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients
JF Biomedical papers
YR 2013
VO 157
IS 4
SP 304
OP 310
DO 10.5507/bp.2013.028
UL https://biomed.papers.upol.cz/artkey/bio-201304-0006.php
AB Aims: Cancer patient's inherited genotype may influence his or her survival, but evidence for the role of these genetic differences in oral cancer survival has not yet been explored.
Methods: The authors evaluated polymorphisms in the GSTM1 and CYP1A1 genes for associations with overall survival in 100 oral squamous cell carcinoma (OSCC) treated patients and 100 controls who were followed up for survival within 2 years of the date of completion of their treatment. Overall survival was evaluated in Kaplan-Meier survival functions and Cox proportional hazards models.
Results: After adjustment for stage and histology, GSTM1null genotype was associated with shorter survival among OSCC patients, compared with GSTM1 present genotype. There was no association between CYP1A1 C genotype and survival in the overall study population.
Conclusion: The study indicated a potential role for GSTM1 polymorphism in predicting the clinical outcomes of treated oral carcinoma patients.