RT Journal Article
SR Electronic
A1 Vrzalikova, Katerina
A1 Woodman, Ciaran Bernard John
A1 Murray, Paul Gerard
T1 BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas
JF Biomedical papers
YR 2012
VO 156
IS 1
SP 1
OP 6
DO 10.5507/bp.2012.003
UL https://biomed.papers.upol.cz/artkey/bio-201201-0001.php
AB Aims: The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas.
Methods and results: This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas.
Conclusions: BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.