PT Journal
AU Vrzalikova, K
   Woodman, C
   Murray, P
TI BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas
SO Biomedical papers
PY 2012
BP 1
EP 6
VL 156
IS 1
DI 10.5507/bp.2012.003
DE BLIMP1; Epstein-Barr virus; DLBCL; review
AB Aims: The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas.Methods and results: This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas.Conclusions: BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.
ER