RT Journal Article
SR Electronic
A1 Stejskal, David
A1 Humenanska, Viera
A1 Hanulova, Zuzana
A1 Fiala, Richard
A1 Vrtal, Radovan
A1 Solichova, Pavlina
A1 Karpisek, Michal
T1 EVALUATION OF URINE N1,N12-DIACETYLSPERMINE AS POTENTIAL TUMOR MARKER FOR URINARY BLADDER CANCER
JF Biomedical papers
YR 2006
VO 150
IS 2
SP 235
OP 237
DO 10.5507/bp.2006.033
UL https://biomed.papers.upol.cz/artkey/bio-200602-0006.php
AB Background: N1,N12-diacetylspermine, a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for a number of cancers. No valid data on urine diacetylspermine concentration in patients with urinary bladder cancer exist.
Aim: Evaluation of urine N1,N12-diacetylspermine concentrations in individuals with urinary bladder cancer.
Methods: Urine samples were used from 36 patients with urothelial tumors of the urinary bladder and from 30 patients with benign urological diseases. Urine was collected before cystoscopy. Enzyme-linked immunoabsorbent assays (ELISA) were performed for diacetylspermine from urine.
Results: Urine diacetylspermine did not differentiate in individuals with urinary bladder cancer from controls (medians 171.5 vs 143.8, p = 0.64). Its efficacy for urinary bladder cancer detection was not shown.
Conclusions: Urine N1,N12-diacetylspermine is probably not a useful marker for urinary bladder cancer.