PT  - JOURNAL ARTICLE
AU  - Stejskal, David
AU  - Humenanska, Viera
AU  - Hanulova, Zuzana
AU  - Fiala, Richard
AU  - Vrtal, Radovan
AU  - Solichova, Pavlina
AU  - Karpisek, Michal
TI  - EVALUATION OF URINE N1,N12-DIACETYLSPERMINE AS POTENTIAL TUMOR MARKER FOR URINARY BLADDER CANCER
DP  - 2006 Dec 1
TA  - Biomedical papers
PG  - 235--237
VI  - 150
IP  - 2
AID - 10.5507/bp.2006.033
IS  - 12138118
AB  - Background: N1,N12-diacetylspermine, a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for a number of cancers. No valid data on urine diacetylspermine concentration in patients with urinary bladder cancer exist.
Aim: Evaluation of urine N1,N12-diacetylspermine concentrations in individuals with urinary bladder cancer.
Methods: Urine samples were used from 36 patients with urothelial tumors of the urinary bladder and from 30 patients with benign urological diseases. Urine was collected before cystoscopy. Enzyme-linked immunoabsorbent assays (ELISA) were performed for diacetylspermine from urine.
Results: Urine diacetylspermine did not differentiate in individuals with urinary bladder cancer from controls (medians 171.5 vs 143.8, p = 0.64). Its efficacy for urinary bladder cancer detection was not shown.
Conclusions: Urine N1,N12-diacetylspermine is probably not a useful marker for urinary bladder cancer.