PT Journal
AU Stejskal, D
   Humenanska, V
   Hanulova, Z
   Fiala, R
   Vrtal, R
   Solichova, P
   Karpisek, M
TI EVALUATION OF URINE N1,N12-DIACETYLSPERMINE AS POTENTIAL TUMOR MARKER FOR URINARY BLADDER CANCER
SO Biomedical papers
PY 2006
BP 235
EP 237
VL 150
IS 2
DI 10.5507/bp.2006.033
DE Urine N1; N12-Diacetylspermine/Urinary Bladder Cancer/ELISA
AB Background: N1,N12-diacetylspermine, a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for a number of cancers. No valid data on urine diacetylspermine concentration in patients with urinary bladder cancer exist.Aim: Evaluation of urine N1,N12-diacetylspermine concentrations in individuals with urinary bladder cancer.Methods: Urine samples were used from 36 patients with urothelial tumors of the urinary bladder and from 30 patients with benign urological diseases. Urine was collected before cystoscopy. Enzyme-linked immunoabsorbent assays (ELISA) were performed for diacetylspermine from urine.Results: Urine diacetylspermine did not differentiate in individuals with urinary bladder cancer from controls (medians 171.5 vs 143.8, p = 0.64). Its efficacy for urinary bladder cancer detection was not shown.Conclusions: Urine N1,N12-diacetylspermine is probably not a useful marker for urinary bladder cancer.
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