Biomedical papers, 2016 (vol. 160), issue 4

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):559-565 | 10.5507/bp.2016.056

Cranberry intervention in patients with prostate cancer prior to radical prostatectomy. Clinical, pathological and laboratory findings

Vladimir Studenta, Ales Vidlara, Jan Bouchalb,c, Jana Vrbkovac, Zdenek Kolarb,c, Milan Krala, Pavel Kosinad, Jitka Vostalovad
a Department of Urology, University Hospital Olomouc, Czech Republic
b Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
c Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
d Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic

Background and Objectives. Recently, we described an inverse association between cranberry supplementation and serum prostate specific antigen (PSA) in patients with negative biopsy for prostate cancer (PCa) and chronic nonbacterial prostatitis. This double blind placebo controlled study evaluates the effects of cranberry consumption on PSA values and other markers in men with PCa before radical prostatectomy.

Methods: Prior to surgery, 64 patients with prostate cancer were randomized to a cranberry or placebo group. The cranberry group (n=32) received a mean 30 days of 1500 mg cranberry fruit powder. The control group (n=32) took a similar amount of placebo. Selected blood/urine markers as well as free and total phenolics in urine were measured at baseline and on the day of surgery in both groups. Prostate tissue markers were evaluated after surgery.

Results: The serum PSA significantly decreased by 22.5% in the cranberry arm (n=31, P<0.05). A trend to down-regulation of urinary beta-microseminoprotein (MSMB) and serum gamma-glutamyltranspeptidase, as well as upregulation of IGF-1 was found after cranberry supplementation. There were no changes in prostate tissue markers or, composition and concentration of phenolics in urine.

Conclusions: Daily consumption of a powdered cranberry fruit lowered serum PSA in patients with prostate cancer. The whole fruit contains constituents that may regulate the expression of androgen-responsive genes.

Keywords: Vaccinium macrocarpon, randomized controlled trial, adenocarcinoma, PSA, cancer markers, urinary metabolites.

Received: September 1, 2016; Accepted: November 1, 2016; Prepublished online: November 10, 2016; Published: December 12, 2016


Attachments:

Download fileBiomed160-4-Student-Supp.pdf

Size290.12 kB

References

  1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, Forman D, Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 2013;49(6):1374-403. doi: 10.1016/j.ejca.2012.12.027 Go to original source... Go to PubMed...
  2. Hackshaw-McGeagh LE, Perry RE, Leach VA, Qandil S, Jeffreys M, Martin RM, Lane JA. A systematic review of dietary, nutritional, and physical activity interventions for the prevention of prostate cancer progression and mortality. Cancer Causes Control 2015;26(11):1521-50. Go to original source... Go to PubMed...
  3. Mayne ST, Playdon MC, Rock CL. Diet, nutrition, and cancer: past, present and future. Natur Rev Clinical Oncol 2016; doi: 10.1038/nrcliorc2016.24 Go to original source...
  4. Willis MS, Wians Jr. FH. The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. Clin Chim Acta 2003;330:57-83. Go to original source... Go to PubMed...
  5. Kallifatidis G, Hoy JJ, Lokeshwar BL. Bioactive products for chemoprevention and treatment of castration-resistant prostate cancer. Semin Cancer Biol 2016, http//dx.doi.org/10.1016/j.semcancer.201606003. Go to original source... Go to PubMed...
  6. Hussain SS, Kumar AP, Ghosh R. Food-based natural products for cancer management: Is the whole greater than the sum of the parts? Semin Cancer Biol 2016 Jul 7. pii: S1044-579X(16)30022-0. doi: 10.1016/j.semcancer.2016.06.002 Go to original source...
  7. Aucoin M, Cooley ND, Knee C, Fritz H, Balneaves LG, Breau R, Fergusson D, Skidmore B, Wong R, Seely D. Fish-Derived Omega-3 Fatty Acids and Prostate Cancer: A Systematic Review. Integr Cancer Ther 2016 Jun 29. pii: 1534735416656052.
  8. Blumberg JB, Camesano TA, Cassidy A, Kris-Etherton P, Howell A, Manach C, Ostertag LM, Sies H, Skulas-Ray A, Vita JA.Cranberries and their bioactive constituents in human health. Adv Nutr 2013;4:618-32. Go to original source... Go to PubMed...
  9. Katsargyris A, Tampaki EC, Giaginis C, Theocharis S. Cranberry as promising natural source of potentional anticancer agents: current evidence and future perspectives. Anticancer Agents Med Chem 2012;12(6):619-30. Go to original source... Go to PubMed...
  10. Déziel BA, Patel K, Neto CC, Gottschall-Pass K, Hurta RA. Proanthocyanidins from the American Cranberry (Vaccinium macrocarpon) inhibit matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways. J Cell Biochem 2010;111(3):742-54. Go to original source... Go to PubMed...
  11. Kondo M, MacKinnon SL, Craft CC, Matchett MD, Hurta RA, Neto CC. Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells. J Sci Food Agric 2011;91(5):789-96. Go to original source... Go to PubMed...
  12. MacLean MA, Scott BE, Deziel BA, Nunnelley MC, Liberty AM, Gottschall-Pass KT, Neto CC, Hurta RA. North American cranberry (Vaccinium macrocarpon) stimulates apoptotic pathways in DU145 human prostate cancer cells in vitro. Nutr Cancer 2011;63(1):109-20. Go to PubMed...
  13. Déziel B, MacPhee J, Patel K, Catalli A, Kulka M, Neto C, Gottschall-Pass K, Hurta R. American cranberry (Vaccinium macrocarpon) extract affects human prostate cancer cell growth via cell arrest by modulating expression of cell cycle regulators. Food Funct 2012;3(5):556-64. Go to original source... Go to PubMed...
  14. Vidlar A, Vostalova J, Ulrichova J,Student V, Stejskal D, Reichenbach R, Vrbkova J, Ruzicka F, Simanek V. The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms. BJN 2010;104:1181-9. Go to original source...
  15. Sumegova K, Nagyova Z, Waczulikova I, Zitnanová I, Duracková Z. Activity of paraoxonase 1 and lipid profile in healthy children. Physiol Res 2007;56:351-3. Go to PubMed...
  16. Jamaspishvili T, Kral M, Khomeriki I, Vyhnankova V, Mgebrishvili G, Student V, Kolar Z, Bouchal J. Quadriplex model enhances urine-based detection of prostate cancer. Prostate Cancer Prostatic Dis 2011;14:354-60. Go to original source... Go to PubMed...
  17. Laxman B, Morris DS, Yu J, Siddiqui J, Cao J, Mehra R, Lonigro RJ, Tsodikov A, Wei JT, Tomlins SA, Chinnaiyan AM.A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer. Cancer Res 2008;68:645-9. Go to original source... Go to PubMed...
  18. Tamura K, Furihata M, Tsunoda T, Ashida S, Takata R, Obara W, Yoshioka H, Daigo Y, Nasu Y, Kumon H, Konaka H, Namiki M, Tozawa K, Kohri K, Tanji N, Yokoyama M, Shimazui T, Akaza H, Mizutani Y, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H. Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles. Cancer Res 2007;67:5117-25. Go to original source... Go to PubMed...
  19. Love HD, Booton SE, Boone BE, Breyer JP, Koyama T, Revelo MP, Shappell SB, Smith JR, Hayward SW. Androgen regulated genes in human prostate xenografts in mice: Relation to BPH and prostate cancer. PLoS ONE 2009;4(12):e8384. Go to original source... Go to PubMed...
  20. Vaarala MH, Hirvikoski P, Kauppila S, Paavonen TK. Identification of androgen-regulated genes in humane prostate. Mol Med Reports 2012;6:466-72.
  21. Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2012; Issue 5, Art.No.:CD001321.
  22. Vidlar A, Student V jr, Vostalova J, Fromentin E, Roller M, Simanek V, Student V. Cranberry fruit powder (FlowensTM) improves lower urinary tract symptoms in men: a double-blind, randomized, placebo-controlled study. World J Urol 2016;34(3):419-24. Go to original source... Go to PubMed...
  23. Martinez-Pinero L, Schalken JA, Cabri P, Maisonobe P, de la Taille A. Triptocare Study Group. Evaluation of urinary prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG score changes when starting androgen-deprivation therapy with triptorelin 6-month formulation in patients with locally advanced and metastatic prostate cancer. BJU Int 2014;114:608-16. Go to original source... Go to PubMed...