Biomedical papers, 2016 (vol. 160), issue 4

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(4):549-552 | 10.5507/bp.2016.023

Effects of rasagiline on freezing of gait in Parkinson's disease - an open-label, multicenter study

František Cibulcika, Jan Benetina, Egon Kurcab, Milan Grofikb, Miloslav Dvorakc, Denis Richterd, Vladimir Donathe, Jan Kothaje, Michal Minarf, Peter Valkovicf
a Department of Neurology, Faculty of Medicine, Slovak Medical University in Bratislava and University Hospital Bratislava, Slovak Republic
b Department of Neurology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin and University Hospital Martin, Slovak Republic
c Department of Neurology, Hospital Spisska Nova Ves, Slovak Republic
d Department of Neurology, University Hospital Bratislava, Slovak Republic
e Department of Neurology, Slovak Health University, Roosevelt Hospital Banska Bystrica, Slovak Republic
f Second Department of Neurology, Faculty of Medicine, Comenius University in Bratislava, Slovak Republic

Aims: Freezing of gait is a disabling symptom in advanced Parkinson's disease. Positive effects have been suggested with MAO-B inhibitors. We report on an open label clinical study on the efficacy of rasagiline as add-on therapy on freezing of gait and quality of life in patients with Parkinson's disease.

Methods: Forty two patients with freezing of gait were treated with 1 mg rasagiline daily as an add-on therapy. Patients were assessed at baseline and after 1, 2 and 3 months of treatment. Freezing of gait severity was assessed using the Freezing of Gait Questionnaire, motor impairment by the modified MDS UPDRS part III, and quality of life using the PDQ-39 questionnaire.

Results: Patients treated with rasagiline had a statistically significant decrease in FoG-Q score and modified MDS UPDRS score after 1, 2 and 3 months of therapy. A moderately strong (r = 0.686, P = 0.002) correlation between the effects on mobility and freezing of gait was found. We also observed a statistically significant improvement in global QoL and in the subscales mobility, ADL, stigma and bodily discomfort in patients after 3 months of rasagiline therapy. A significant correlation (r = 0.570, P = 0.02) between baseline FoG-Q score and the baseline score for the PDQ Mobility subscale was found.

Conclusion: In our study rasagiline as add-on antiparkinsonian therapy significantly improved mobility, freezing of gait and quality of life. The positive effect on freezing of gait appears to be related to improvement of mobility.

Keywords: Parkinson's disease, freezing of gait, Rasagiline

Received: February 22, 2016; Accepted: April 13, 2016; Prepublished online: April 21, 2016; Published: December 12, 2016


References

  1. Giladi N. Medical treatment of freezing of gait. Mov Disord 2008;23:S482-S488. Go to original source... Go to PubMed...
  2. Giladi N, Shabtai H, Simon ES, Biran S, Tal J, Korczyn AD. Construction of freezing of gait questionnaire for patients with Parkinsonism. Parkinsonism Relat Disord 2000;6:165-70. Go to original source... Go to PubMed...
  3. Goetz CG, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stebbins GT, Stern MB, Tilley BC, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, Van Hilten JJ, LaPelle N. Movement disorder society-sponsored revision of the Unified Parkinson's disease rating scale (MDS-UPDRS): process, format, and clinimetric testing plan. Mov Disord 2007;22:41-7. Go to original source... Go to PubMed...
  4. Peto V, Jenkinson C, Fitzpatrick R, Greenhall R. The development and validation of a short measure of functioning and well-being for individuals with Parkinson's disease. Qual Life Res 1995;4:241-8. Go to original source... Go to PubMed...
  5. Martinez-Martin P, Jeukens-Visser M, Lyons KE, Rodriguez-Blazquez C, Selai C, Siderowf A et al. Health-related quality-of-life scales in Parkinson's disease: critique and recommendations. Mov Disord 2011;26:2371-80. Go to original source... Go to PubMed...
  6. Coria F, Cozar-Santiago MP: Rasagiline improves freezing in patient with primary progressive freezing gait. Mov Disord 2008;23:449-51. Go to original source... Go to PubMed...
  7. Levin OS, Boiko AN, Ivanov AK. Efficacy of rasagiline in patients with advanced Parkinson's disease with motor fluctuation (Azimut study). Zh Nevrol Psikhiatr Im S S Korsakova 2010;110:42-7. Go to PubMed...
  8. Rascol 0, Brooks DJ, Melamed E, Oertel W, Poewe W, Stocchi F, Tolosa E. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once Daily): a randomised, double-blind, parallel-group trial. Lancet 2005;365:947-54. Go to PubMed...
  9. Giladi N, Rascol O, Melamed E, Oertel W, Poewe W, Stocchi F, Tolosa E. Rasagiline treatment can improve freezing of gait in advanced Parkinson's disease: A prospective, randomised, double blind, placebo and entacapone controlled study. Mov Disord 2004;19:S191-2.
  10. Rahman S, Griffin HJ, Quinn NP, Jahanshahi M. Quality of life in Parkinson's disease: the relative importance of the symptoms. Mov Disord 2008;23:1428-34. Go to original source... Go to PubMed...
  11. Martinez-Martin P, Deuschl G. Effect of medical and surgical interventions on health-related quality of life in Parkinson's disease. Mov Disord 2007;22:757-65. Go to original source... Go to PubMed...
  12. Biglan KM, Schwid S, Eberly S, Blindauer K, Fahn S, GorenT, Kieburtz K, Oakes D, Plumb S, Siderowf A, Stern M, Shoulson I; Parkinson Study Group. Rasagiline improves quality of life in patients with early Parkinson's disease. Mov Disord 2006;21:616-23. Go to original source... Go to PubMed...