Biomedical papers, 2016 (vol. 160), issue 3

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(3):417-422 | 10.5507/bp.2016.027

The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance

Martin Broza, Petr Steinerb, Richard Salzmana, Lukas Hauerc, Ivo Stareka
a Department of Otorhinolaryngology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
b Bioptic Laboratory Ltd, Molecular Pathology Laboratory, Pilsen and Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Pilsen, Czech Republic
c Department of Maxillofacial Surgery, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic

Aims: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters

Methods: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis.

Results: Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative. The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P=0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients.

Conclusion: A tendency to differences in the survival of patients with ACC, depending on their MYB status. MYB negative patients were predisposed to better prognosis.

Keywords: adenoid cystic carcinoma, MYB gene, salivary gland, prognosis

Received: November 27, 2015; Accepted: April 27, 2016; Prepublished online: May 12, 2016; Published: September 20, 2016


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