Biomedical papers, 2016 (vol. 160), issue 2

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016, 160(2):219-221 | 10.5507/bp.2016.019

Omentin-1 levels in patients with premature coronary artery disease, metabolic syndrome and healthy controls. Short communication

David Stejskala,b,c, Jan Vaclavikd, Ales Smekald, Gabriela Svobodovaa,b, Radmila Richterovae, Marek Svestaka,b
a AGEL Research and Training Institute, Prostejov, Czech Republic
b Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
c Department of Biomedical Sciences, Faculty of Medicine, Ostrava University, Czech Republic
d Department of Internal Medicine I - Cardiology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
e Agel Laboratories, Novy Jicin, Czech Republic

Objectives: Omentin-1 is an adipokine which could have a protective role against the manifestation of atherosclerosis. Only limited data are available on omentin-1 serum values in patients with premature clinical manifestations of atherosclerosis. Design and Methods. We tested omentin-1 in human serum by ELISA method in 61 individuals with a premature manifestation of coronary artery disease (CAD), 40 patients with metabolic syndrome and 40 healthy control subjects.

Results: Omentin-1 serum levels were significantly lower in patients with CAD (103.1±62.7 mg/L) compared to metabolic syndrome (668.2±339.6 mg/L) and healthy subjects (623.0±373.5 mg/L) (P < 0.01). In CAD patients, omentin-1 serum levels did not differ between patients sampled in the acute phase of myocardial infarction (n = 28; 110.3±82.4 mg/L) and in the chronic phase several months or years after myocardial infarction (n = 33; 97.0±39.3 mg/L) (P = 0.41). We found a weak positive correlation between omentin-1 and body mass index (r = 0.21, P = 0.014). No significant correlation was found between peak cardiac troponin T and omentin-1 (correlation coefficient r = 0.118, P = 0.406).

Conclusion: Serum omentin-1 seems to be a useful biomarker of coronary artery disease across the whole age spectrum.

Keywords: omentin-1, acute myocardial infarction, coronary artery disease, premature manifestation, adipokines, ELISA

Received: November 12, 2015; Accepted: March 30, 2016; Prepublished online: April 20, 2016; Published: June 24, 2016


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