Biomedical papers, 2009 (vol. 153), issue 1

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009, 153(1):59-62 | 10.5507/bp.2009.010

Peripheral nerve involvement and severity of motor disorder in Parkinson\'s disease: a correlational study

Zuzana Chovancova, Petr Kanovsky, Jaroslav Dufek, Martin Nevrly, Pavel Otruba
Department of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Center for the Diagnosis and Treatment of Neurodegenerative Diseases, Czech Republic

BACKGROUND: The aim of thisstudy was to test the hypothesis that there is concomitant peripheral nerve involvement in patients suffering from neurodegenerative disorders by correlating motor and peripheral nerve involvement in Parkinson's disease.

METHODS AND RESULTS: A total of 23 patients suffering from Parkinson's disease diagnosed strictly according to the UKPDBB criteria were examined. The group comprised 14 males (mean age: 57 years, mean age at onset: 51years, mean duration of disease: 7 years, mean duration of dopaminergic treatment: 4 years) and 9 females (mean age: 67 years, mean age at onset: 63 years, mean duration of disease: 4 years, mean duration of dopaminergic treatment: 1 year).

CONCLUSION: Polyneuropathy was clinically present and confirmed using EMG examination in 10 patients (43.5 %), 5 males and 5 females. This suggests that the neurodegenerative process involves both the central and the peripheral nervous system in Parkinson's patients.

Keywords: Parkinson’s disease, Polyneuropathy, Electromyography, Correlation

Received: January 1, 1970; Accepted: November 10, 2008; Published: March 1, 2009


References

  1. Braak H, Del Tredici K, Rüb U, et al. Staging of brain pathology related to sporadic Parkinsons disease. Neurobiology of Aging 24, 2003: 197-211. Go to original source... Go to PubMed...
  2. Abbruzzese G, Pigullo S, Schenone A, Bellone E, Marchese R, Di Maria E, Benedetti L, ciotti P, Nobbio L, Bonifati V, Ajmar F, Mandich P. Does parkin play a role in the peripheral nervous system? A family report. Mov Disord 2004; 18: 978-981. Go to original source... Go to PubMed...
  3. Rodolico C, Toscano A, De Luca G, Mazzeo A, Di Leo R, Baldari S, Girlanda P, Vita G. Peripheral neuropathy as the presenting feature of multiple system atrophy. Clin Autonom Res 2001; 11:63. Go to original source... Go to PubMed...
  4. Taly AB, Mutane UB. Involvement of peripheral nervous system in juvenile Parkinsons disease. Acta Neurol Scand 1992; 85: 272-275. Go to original source... Go to PubMed...
  5. Abele M, Schulz JB, Burk K, Topka H, Dichgans J, Klockgether T. Nerve conduction studies in multiple system atrophy. Eur Neurol 2000;43: 221-223. Go to original source... Go to PubMed...
  6. Becker G, Muller A, Braune S, Buttner T, Benecke R, Greulich W, Klein W, Mark G, Rieke G, Thumler R. Early diagnosis of Parkinsons disease. J Neurol 2002; 249 (Suppl.3): 40-48. Go to original source... Go to PubMed...
  7. Geser F, Wenning GK. The diagnosis of multiple system atrophy. J Neurol. 2006; 253 (suppl.3). Go to original source... Go to PubMed...
  8. Hoehn MM, Mahr MD. Parkinsonism: onset, progression and mortality Neurology 1967, 17: 427-42. Go to original source... Go to PubMed...
  9. Chovancova Z, Kanovsky P, Nestrasil I, Dufek J. Peripheral nerves injury in the central nervous system degeneration: pilot study (abstract). Movement Disorders, Vol 21, Suppl. 15, 2006, pp. S362-S363.
  10. Nevrly M, Vranova H, Ressner P, Nestrasil I, Kanovsky P. Effect of levodopa and entacapone treatment on plasma homocysteine level in Parkinson disease: pilot study. (abstract) Movement Disorders, Vol 21, Suppl. 15, 2006, pp. S545.
  11. Tolosa E, Wenning G, Poewe W. The diagnosis of Parkinsons disease. Lancet Neurol. 2006; 5: 75-86 Go to original source... Go to PubMed...
  12. Dumitru D, Amato AA, Zwarts MJ. Electrodiagnostic medicine. Second edition. Hanley and Belfus: Philadelphia 2002, s. 921-923.
  13. Hallett M ad. Handbook of Clinical Neurophysiology, Vol 1, Movement disorders, 1st Edition, Philadelphia, Elsevier 2003: 7-19
  14. Pramstaller PP, Wenning GK, Smith SJ, Beck RO, Quinn NP, Fowler CJ. Nerve conduction studies, skeletal muscle EMG, and sphincter EMG in multiple system atrophy. J Neurol 1985; 42: 695-696.
  15. Hughes AJ, Daniel SE, Kilford L, Lees AJ et all. Accuracy of clinical diagnosis of idiopathic Parkinsons disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1993 Aug; 56(8):938-9. Go to original source... Go to PubMed...