Biomedical papers, 2006 (vol. 150), issue 1

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006, 150(1):25-38 | 10.5507/bp.2006.003

ULTRAVIOLET LIGHT INDUCED ALTERATION TO THE SKIN

Alena Svobodova, Daniela Walterova, Jitka Vostalova
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Hněvotínská 3, 775 15 Olomouc, Czech Republic

Solar light is the primary source of UV radiation for all living systems. UV photons can mediate damage through two different mechanisms, either by direct absorption of UV via cellular chromophores, resulting in excited states formation and subsequent chemical reaction, or by phosensitization mechanisms, where the UV light is absorbed by endogenous (or exogenous) sensitizers that are excited and their further reactions lead to formation of reactive oxygen species (ROS). These highly reactive species can interact with cellular macromolecules such as DNA, proteins, fatty acids and saccharides causing oxidative damage. Direct and indirect injuries result in a number of harmful effects such as disrupted cell metabolism, morphological and ultrastructural changes, attack on the regulation pathways and, alterations in the differentiation, proliferation and apoptosis of skin cells. Processes like these can lead to erythema, sunburn, inflammation, immunosuppression, photoaging, gene mutation, and development of cutaneous malignancies. The endogenous and exogenous mechanisms of skin photoprotection are discussed.

Keywords: UV radiation, Skin, DNA damage, Reactive oxygen species (ROS), p53, Antioxidant enzymes

Received: April 28, 2006; Accepted: May 15, 2006; Published: July 1, 2006


References

  1. Melnikova VO, Ananthaswamy NH. (2005) Cellular and molecular events leading to the development of skin cancer. Mutat Res 571, 91106. Go to original source... Go to PubMed...
  2. Hussein MR. (2005) Ultraviolet radiation and skin cancer: molecular mechanisms. J Cutan Pathol 32, 191205. Go to original source... Go to PubMed...
  3. Clydesdale GJ, Dandie GW, Muller HK. (2001) Ultraviolet light induced injury: Immunological and inflammatory effests. Immunol Cell Biol 79, 54768. Go to original source... Go to PubMed...
  4. Duthie MS, Kimber I, Norval M. (1999) The effects of ultraviolet radiation on the human immune system. Br J Dermatol 140, 9951009. Go to original source... Go to PubMed...
  5. De Gruijl FR, Van der Leun JC. (2000) Environment and health: 3. Ozone depletion and ultraviolet radiation. CMAJ 163, 8515. Go to PubMed...
  6. Afaq F, Mukhtar H. (2001) Effects of solar radiation on cutaneous detoxification pathways. J Photochem Photobiol B 63, 619. Go to original source... Go to PubMed...
  7. Afaq F, Mukhtar H. (2002) Photochemoprevention by botanical antioxidants. Skin Pharmacol Appl Skin Physiol 15, 297306. Go to original source... Go to PubMed...
  8. Trautinger F. (2001) Mechanisms of photodamage of the skin and its functional consequences for skin agening. Clin Exp Dermatol 26, 5737. Go to original source... Go to PubMed...
  9. De Gruijl RR. (2002) Photocarcinogenesis: UVA vs. UVB radiation. Skin Pharmacol Appl Skin Physiol 15, 31620. Go to original source... Go to PubMed...
  10. Pattison DI, Davies MJ. (2006) Actions of ultraviolet light on cellular structures. EXS 96, 13157. Go to PubMed...
  11. Petit Frere C, Clingen PH, Arlett CF, Green MH. (1996) Inhibition of RNA and DNA synthesis in UV-irradiated normal human fibroblasts is correlated with pyrimidine (6-4) pyrimidone photoproduct formation. Mutat Res 354, 8794. Go to original source... Go to PubMed...
  12. Van der Leun JC. (2004) The ozone layer. Photodermatol Photoimmunol Photomed 20, 15962. Go to original source...
  13. Heck DE, Gerecke DR, Vetrano AM, Laskin JD. (2004) Solar ultraviolet radiation as a trigger of cell signal transduction. Toxicol Appl Pharmacol 195, 28897. Go to original source... Go to PubMed...
  14. Godar DE. (2005) UV doses worldwide. Photochem Photobiol 81, 73649. Go to original source... Go to PubMed...
  15. Kanofsky JR, Sima P. (1991) Singlet oxygen production from the reactions of ozone with biological molecules. J Biol Chem 266, 903942. Go to PubMed...
  16. Thiele J, Elsner P. Oxidants and antioxidants in cutaneous biology. Basel: Karger, 2001.
  17. Kulms D, Schwarz T. (2000) Molecular mechanisms of UV-induced apoptosis. Photodermatol Photoimmunol Photomed 16, 195201. Go to original source... Go to PubMed...
  18. Norval M, El-Ghorr AA. (2002) Studies to determine the immunomodulating effects of cis-urocanic acid. Methods 28, 6370. Go to original source... Go to PubMed...
  19. Ischihashi M, Ueda M, Budiyanto A, Bito T, Oka M, Fukunaga M, Tsuru K, Horikawa T. (2003) UV-induced skin damage. Toxicology 189, 2139. Go to original source... Go to PubMed...
  20. Matsumura Y, Ananthaswamy HN. (2004) Toxic effects of ultraviolet radiation on the skin. Toxicol Appl Pharmacol 195, 298308. Go to original source... Go to PubMed...
  21. Kappes UP, Luo D, Potter M, Schulmeister K, Runger. (2006) Short- and long-wave UV light (UVB and UVA) induce similar mutations in human skin cells. J Invest Dermatol 126, 66775. Go to original source... Go to PubMed...
  22. Sander CS, Chang H, Hamm F, Elsner P, Thiele JJ. (2004) Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis. Int J Dermatol 43, 32635. Go to original source... Go to PubMed...
  23. Inal ME, Kahramant A, Kökent T. (2001) Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clin Exp Dermatol 26, 5369. Go to original source... Go to PubMed...
  24. Halliday GM. (2005) Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contribute to photocarcinogenesis. Mutat Res 571, 10720. Go to original source... Go to PubMed...
  25. Nishigori C, Hattori Y, Toyokuni S. (2004) Role of reactive oxygen species in skin carcinogenesis. Antioxid Redox Signal 6, 56170. Go to original source... Go to PubMed...
  26. Pinnell SR. (2003) Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol 48, 119. Go to original source... Go to PubMed...
  27. Katiyar SK, Elmets CA. (2001) Green tea antioxidants and skin photoprotection. Int J Oncol 18, 130713. Go to original source... Go to PubMed...
  28. Grandjean-Laquerriere A, Le Naour R, Gangloff SC, Guenounou M. (2003) Differential regulation of TNF-alpha, IL-6 and IL-10 in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway. Cytokine 23, 13849. Go to original source... Go to PubMed...
  29. Halliday G, Bryne SN, Kuchel JM, Poon TS, Barnetson RS. (2004) The suppression of immunity by ultraviolet radiation: UVA, nitric oxide and DNA damage. Photochem Photobiol Sci 3, 73640. Go to original source... Go to PubMed...
  30. Scharffetter-Kochanek K, Brenneisen P, Wenk J, Herrmann G, Ma W, Kuhr L, Meewes C, Wlaschek M. (2000) Photoaging of the skin: from phenotype to mechanisms. Exp Geront 35, 30716 Go to original source... Go to PubMed...
  31. Lavker RM, Gerberick GF, Veres D, Irwin CJ, Kaidbey KH. (1995) Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin. J Am Acad Dermatol 32, 53 62. Go to original source... Go to PubMed...
  32. Onoue S, Kobayashi T, Takemoto Y, Sasaki I, Shinkai H. (2003) Induction of matrix metalloproteinase-9 secretion from human keratinocytes in culture by ultraviolet B irradiation. J Dermatol Sci 33, 10511. Go to original source... Go to PubMed...
  33. Lee JL, Mukhtar H, Bickers DR, Kopelovich L, Athar M. (2003) Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol Appl Pharmacol 192, 294306. Go to original source... Go to PubMed...
  34. Mahns A, Wolber R, Stab F, Klotz LO, Sies H. (2004) Contribution of UVB and UVA to UV-dependent stimulation of cyclooxygenase- 2 expression in artificial epidermis. Photochem Photobiol Sci 3, 25762. Go to original source... Go to PubMed...
  35. Allanson M, Reeve VE. (2005) Ultraviolet A (320-400 nm) modulation of ultraviolet B (290-320 nm)-induced immune suppression is mediated by carbon monoxide. J Invest Dermatol 124, 64450. Go to original source... Go to PubMed...
  36. Obermuller-Jevic UC, Schlegel B, Flaccus A, Biesalski HK. (2001) The effect of beta-carotene on the expression of interleukin-6 and heme oxygenase-1 in UV-irradiated human skin fibroblasts in vitro. FEBS Lett 509, 18690. Go to original source... Go to PubMed...
  37. Basu-Modak S, Luscher P, Tyrrell RM. (1996) Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene. Free Radic Biol Med 20, 88797. Go to original source... Go to PubMed...
  38. Tyrrell RM. (2004) Solar ultraviolet A radiation: an oxidizing skin carcinogen that activates heme oxygenase-1. Antioxid Redox Signal 6, 83540. Go to original source...
  39. Kvam E, Noel A, Basu-Modak S, Tyrrell RM. (1999) Cyclooxygenase dependent release of heme from microsomal hemeproteins correlates with induction of heme oxygenase 1 transcription in human fibroblasts. Free Radic Biol Med 26, 5117. Go to original source... Go to PubMed...
  40. Paunel AN, Dejam A, Thelen S, Kirsch M, Horstjann M, Gharini P, Murtz M, Kelm M, Groot H, Kolb.Bachofen V, Suschek CV. (2005) Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms. Free Radic Biol Med 38, 60615. Go to original source... Go to PubMed...
  41. Chang HR, Tsao DA, Wang SR, Yu HS. (2003) Expression of nitric oxide synthases in keratinocytes after UVB irradiation. Arch Dermatol Res 295, 2936. Go to original source... Go to PubMed...
  42. Cals-Grierson MM, Ormerod AD. (2004) Nitric oxide function in the skin. Nitric Oxide 10, 17993. Go to original source... Go to PubMed...
  43. Hillebrand GG, Wilsow MS, Benzinger MJ, Heitmeyer DA, Bissett DL. (1990) Acute and chronic ultraviolet radiation induction of epidermal ornithine decarboxylase activity in hairless mice. Cancer Res 50, 15804. Go to PubMed...
  44. Arnold WP, Pennings BJ, van de Kerkhof PC. (1992) The induction of ornithine decarboxylase in human epidermis is independent of lipoxygenase and cyclo-oxygenase pathways. J Dermatol 19, 4614. Go to original source... Go to PubMed...
  45. Francz PI, Conrad J, Biesalski HK. (1998) Modulation of UVAinduced lipid peroxidation and suppression of UVB-induced ornithine decarboxylase response by all-trans-retinoic acid in human skin fibroblasts in vitro. Biol Chem 379, 12639. Go to original source... Go to PubMed...
  46. Katiyar SK, Matsui MS, Mukhtar H. (2000) Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1. J Invest Dermatol 114, 32833. Go to original source... Go to PubMed...
  47. Gonzalez MC, Marteau C, Franchi J, Migliore-Samour D. (2001) Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation. Br J Dermatol 145, 74957. Go to original source... Go to PubMed...
  48. Lear JT, Smith AG, Strange R, Fryer AA. (2000) Detoxifying enzyme genotypes and susceptibility to cutaneous malignancy. Br J Dermatol 142, 815. Go to original source... Go to PubMed...
  49. Villard PH, Sampol E, Elkaim JL, Puyoou F, Casanova D, Seree E, Durand A, Lacarelle B. (2002) Increase of CYP1B1 transcription in human keratinocytes and HaCaT cells after UV-B exposure. Toxicol Appl Pharmacol 178,13743. Go to original source... Go to PubMed...
  50. Vile GF, Tanew-Ilitschew A, Tyrrell RM. (1995) Activation of NFkappa B in human skin fibroblasts by the oxidative stress generated by UVA radiation. Photochem Photobiol 62, 4638. Go to original source... Go to PubMed...
  51. Loercher A, Lee TL, Ricker JL, Howard A, Geoghegen J, Chen Z, Sunwoo JB, Sitcheran R, Chuang EY, Mitchell JB, Baldwin AS Jr, Van Waes C. (2004) Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. Cancer Res 64, 651123. Go to original source... Go to PubMed...
  52. Gillardon F, Eschenfelder C, Uhlmann E, Hartschuh W, Zimmermann M. (1994) Differential regulation of c-fos, fosB, cjun, junB, bcl-2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion. Oncogene 9, 321925. Go to PubMed...
  53. Sasaki H, Akamatsu H, Horio T. (1997) Effects of a single exposure to UVB radiation on the activities and protein levels of copper-zinc and manganese superoxide dismutase in cultured human keratinocytes. Photochem Photobiol 65, 70713. Go to original source... Go to PubMed...
  54. Naderi-Hachtroudi L, Peters T, Brenneisen P, Meewes C, Hommel C, Razi-Wolf Z, Schneider LA, Schuller J, Wlaschek M, Scharffetter-Kochanek K. (2002) Induction of manganese superoxide dismutase in human dermal fibroblasts: a UV-B-mediated paracrine mechanism with the release of epidermal interleukin 1 alpha, interleukin 1 beta, and tumor necrosis factor alpha. Arch Dermatol 138, 14739. Go to original source... Go to PubMed...
  55. Harris RB, Alberts DS. (2004) Strategies for skin cancer prevention. Int J Dermatol 43, 24351. Go to original source... Go to PubMed...
  56. Haywood R, Wardman P, Sanders R, Linge C. (2003) Sunscreens inadequately protect against ultraviolet-A- induced free radicals in skin: implications for skin aging and melanoma? J Invest Dermatol 121, 8628. Go to original source... Go to PubMed...
  57. Wolf R, Wolf D, Morganti P, Ruocco V. (2001) Sunscreens. Clin Dermatol 19, 4529. Go to original source... Go to PubMed...
  58. Diffey B. (2001) Sunscreen isnt enough. J Photochem Photobiol B 64,1058. Go to original source... Go to PubMed...
  59. Herzog B, Mongiat S, Quass K, Deshayes C. (2004) Prediction of sun protection factors and UVA parameters of sunscreens by using a calibrated step film model. J Pharm Sci 93, 178095. Go to original source... Go to PubMed...
  60. Rosen CF. (2003) Topical and systemic photoprotection. Dermatol Ther 16, 815. Go to original source... Go to PubMed...
  61. Nash JF. (2006) Human safety and efficacy of ultraviolet filters and sunscreen products. Dermatol Clin 24, 3551. Go to original source...
  62. Ettler K. Fotoprotekce kůže. Ochrana kůže před účinky ultrafialového záření. Praha: TRITON s.r.o., 2004.
  63. Armeni T, Damiani E, Battino M, Greci L, Principato G. (2004) Lack of in vitro protection by a common sunscreen ingredient on UVA-induced cytotoxicity in keratinocytes. Toxicology 203, 16578. Go to original source... Go to PubMed...
  64. Fguyer S, Afaq F, Mukhtar H. (2003) Photochemoprevention of skin cancer by botanical agents. Photodermatol Photoimmunol Photomed 19, 5672. Go to original source...
  65. Svobodova A, Psotova J, Walterova D. (2003) Natural phenolics in the prevention of UV-induced skin damage. A review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147, 13745. Go to original source...
  66. Hsu S. (2005) Green tea and the skin. J Am Acad Dermatol 52, 104959. Go to original source... Go to PubMed...
  67. Katiyar SK. (2005) Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (Review). Int J Oncol 26, 16976. Go to original source... Go to PubMed...
  68. Singh RP, Agarwal R. (2005) Mechanism and preclinical efficacy of silibinin in preventing skin cancer. Eur J Cancer 41, 196979. Go to original source... Go to PubMed...
  69. Gonzales S, Pathak MA. (1996) Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomos. Photodermatol Photoimmunol Photomed 12, 4556. Go to original source...
  70. Bonte F, Meybeck A, Dumas M.(LVMH Recherche):WO 92/21322 (10. 12. 1992).
  71. Offord EA, Gautier JC, Avanti O, Scaletta C, Runge F, Krämer K, Applegate LA. (2002) Photoprotective potential of lycopene, b-carotene, vitamin E, vitamin C, and Carnosic acid in UVA-irradiated human skin fibroblast. Free Radic Biol Med 32, 12931303. Go to original source... Go to PubMed...
  72. Erden Inal M, Kahramant A, Kökent T. (2001) Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clin Exp Dermatol 26, 5369. Go to original source... Go to PubMed...
  73. Basu-Modak S, Gordon MJ, Dobson LH, Spencer JP, Rice-Evans C, Tyrrell RM. (2003) Epicatechin and its methylated metabolite attenuata UVA-induced oxidative damage to human skin fibroblasts. Free Radic Biol Med 35, 91021. Go to original source... Go to PubMed...
  74. Tobi SE, Gilbert M, Paul N, McMillan TJ. (2002) The green tea polyphenol, epigallocatechin-3-gallate, protects against the oxidative cellular and genotoxic damage of UVA radiation. Int J Cancer 102, 43944. Go to original source... Go to PubMed...
  75. Huang CC, Fang JY, Wu WB, Chiang HS, Wei YJ, Hung CF. (2005) Protective effects of (-)-epicatechin-3-gallate on UVA-induced damage in HaCaT keratinocytes. Arch Dermatol Res 296, 47381. Go to original source... Go to PubMed...
  76. Philips N, Smith J, Keller T, Gonzales S. (2003) Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase- 1 in ultraviolet radiation exposed fibroblasts, and keratinocytes. J Dermatol Sci 32, 19. Go to original source... Go to PubMed...
  77. Svobodova A, Zdarilova A, Maliskova J, Mikulkova H, Walterova D, Psotova J. (2006) Attenuation of UVA-induced oxidative damage to human keratinocytes by silymarin. Free Radic Biol Med (submitted).
  78. Psotova J, Svobodova A, Kolarova H, Walterova D. (2006) Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes. J Photochem Photobiol B (accepted). Go to original source...